If anyone asks, no I am NOT procrastinating writing my feature. I am just SO PASSIONATE about science news that I think it takes precedence..especially when the news carries the hint of something that might cure what really ails me: allergies.
As many of you know, I am allergic to most everything. Dust, mold, pollen, grass, cats, dogs, horses, pretty much anything cute and cuddly with hair or feathers, all nuts, peanuts, eggs and shellfish. I carry a self-injectable syringe full of adrenalin where ever I go and a large stock pile of several different anti-histamines. I am still waiting to develop my allergies to wheat, milk and oxygen. I know they'll show up eventually.
Anyway. So what is up with my immune system, eh? To the best of our knowledge, allergies are the result of some short circuit with the T helper cells, specifically Th2 cells. It is this kind of white blood cell that is normally responsible for fending off parasites - like worms n' stuff. The deeper cause is still a mystery but likely has something to do with the regulatory T cells (Treg) that control the production of both Th1 (which fight viruses and bacteria) and Th2. There are deeper connections still, but I am thinking you want me to stop now.
Basically, immunologists figure that our hyper-clean and generally infection-free environment has left our Tregs/Th1/Th2 with nothing much to do, so they fill their time by attacking perfectly harmless proteins, like those from peanuts, trying to kill me in the process.
Going with this hypothesis, companies around the world have been attempting to mimic infections in order to suppress the allergic response. One of the pioneers is a German company called OvaMed. They having been using the eggs of a pig intestinal worm (which cannot reproduce in human, cutting down on the gross factor) to treat severe autoimmune disorders such as Crohn's Disease. And it seems to work. They are starting to conduct trials on food allergies. Let's all pray. Personally, if am going to swallow worms, I'd at least like it to be a tapeworm, because then I'd get to be thin. Thin and allergy free..these are the stuff of dreams.
Anyway. I am rambling (who said procrastination?..take that back right now!). So this Swiss company is now attempting shut off allergies by stimulating Th1 cells via injections of mycobacteria. Yummy. Upping the Th1 response seems to shut down the Th2 (allergy) response, likely through Tregs. Ha!
Again, if someone could just come up with an allergy fighting tape worm that was easily extractable after the desired weight loss and allergy reversal, they would make a FORTUNE. The obesity epidemic in our great Western nations is really only topped by the massive spread of allergic disease. And they say all the good ideas are taken.